Receptor Tyrosine Kinases as Target for Anti-Cancer Therapy
نویسندگان
چکیده
منابع مشابه
Tyrosine kinases as targets for cancer therapy.
Enhanced protein tyrosine kinase (PTK) activity correlates with the development of cancer and other proliferative diseases. The hypothesis that PTK inhibitors may be of value in the treatment of cancer led to the systematic synthesis of selective tyrosine phosphorylation inhibitors (tyrphostins) that show in vitro and in vivo anticancer activity. This review will provide an overview of research...
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Tight control of cell proliferation and morphogenesis in conjunction with programmed cell death (apoptosis) is required to ensure normal tissue patterning. Alterations that cause an imbalance of the cellular signals that control these events may promote cell growth, suppress apoptosis, and enhance cell invasion, resulting in oncogenesis. Many of these signals are regulated by receptor tyrosine ...
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ژورنال
عنوان ژورنال: Current Pharmaceutical Design
سال: 2002
ISSN: 1381-6128
DOI: 10.2174/1381612023393530